The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity
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چکیده
منابع مشابه
The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity
During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been proposed to explain how the initial differences between these two cell populat...
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In preimplantation mouse development, the first cell lineages to be established are the trophectoderm (TE) and inner cell mass. TE possesses epithelial features, including apical-basal cell polarity and intercellular junctions, which are crucial to generate a fluid-filled cavity in the blastocyst. Homologs of the partitioning defective (par) genes in Caenorhabditis elegans are critical regulato...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2017
ISSN: 2046-2441
DOI: 10.1098/rsob.170210